Is a multi-disciplinary field in medicine, in which different therapeutic interventions are utilized, in order to induce biologic enhancement of tissue repair, regeneration and functional restoration.
Are personalized and precise interventions, in which growth factors, scaffolds and cells are utilized, in order to induce biologic enhancement of tissue repair, regeneration and functional restoration of specific damaged or degenerative tissues.
The first definition of tissue engineering is attributed to Drs. Langer and Vacanti who stated it to be, “an interdisciplinary field that applies the principles of engineering and life sciences towards, the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ”.
2. Elements of Regenerative Medicine:
In order to maximize the outcome of regenerative medicine interventions, it is paramount to understand the concept of (niche) optimization. The niche is a term use to describe the area in which a regenerative intervention is considered. For example, the knee joint, the lumbar disc, the torn ligament. It is affected by numerous factors such as: local blood supply, biomechanics, presence of local and systemic inflammatory proteins and the overall health of the human body.
To use a gardening analogy is the most effective way to describe the interactions which takes place, in the treatment of injured or degenerative tissues. If an area of the garden shows a significant deterioration of the local population of roses and begonias. The wise gardener does not plant new seeds (stem cells) or add more fertilizer (platelet rich plasma) and expect immediate results. The gardener, evaluates the whole garden then looks for clues in order to restore the health of the garden. He or she looks for diseases, sun exposure, watering pattern, quality of the top soil, toxins or poison, etc. Once these factors are corrected, the seeds are planted and the soil fertilized. The human body is the whole garden, and the specific niche (knee, disc, tendon) corresponds to the damaged areas.
We believe that in order to provide the best care for our patients, it is imperative to look at the overall health of the system, rather than just a body part. This is done by identifying the essential elements of Regenerative Medicine: Lifestyle, Nutrition and Hormonal Balance.
- Factors that affect the regenerative process in a negative way.
- Smoking: Decrease blood supply, damage nerves
- Sedentary Lifestyle : Poor body mechanics, increase inflammation, poor blood supply
- Alcohol, Drugs: Toxic to cells, accelerate cognitive decline
- Excessive Weight: Excessive load on joints, increase inflammation
- Stress: Affects the ability to fight infection, decrease healing
- Lack of exercise: Decreases blood flow, increase osteoporosis, obesity
The following dietary habits will create a suboptimal environment for tissue regeneration.
- Sugars: pro-inflammatory, gut dysfunction, hormonal imbalance,
- Saturated Fats: pro-inflammatory, gut dysfunction, heart disease, etc
- Carbonated drinks: inhibit absorption of calcium, phosphorus, weak bones
- Lack of proper Vitamins and Minerals: increase risk of osteoporosis, lowers the body’s ability to process free radicals, increase cancer risks, etc
Deficiency or sub-optimal levels of hormones area associated with significant disease states and co-morbidities.
- Estrogen: vascular health, depression, fatigue
- Progesterone: bone health, tissue healing, mental health
- Testosterone: muscle and bone loss, poor healing, increase inflammation
- Cortisol: Excess: increase inflammation, diabetes, mental health
- Growth Hormone: decrease healing, increase inflammation, muscle loss, etc
When we address most of the conditions described above, not only our results improve dramatically, but most importantly, the patient overall health and well being is restored.
III. The B.E.T.R. Technique
It stands for Biologic Enhancement of Tissue Repair and Regeneration. We believe this term explains the nature of how regenerative medicine interventions work. By adhering to the most advanced principles of tissue engineering, we are able to provide individualized, precise and cost effective treatments to every patient.
According to the severity of the injury or degenerative condition, a decision is made as to which level of BETR technique is indicated. The basic principle of tissue engineering requires that for optimal tissue regeneration, three elements most be present. A Biologic Stimulants (growth factors), Cells (multiple types including stem cells) and Tissue Scaffolds (such a collagen, adipose tissue or fibrin, which allows the tissue to heal in an organized way).