Bio-Cellular Regenerative Therapy Is a broad term that describes the use of different substances, cells and tissue grafts, in order to induce biologic enhancement of tissue repair and regeneration.Â It is an integral part of Tissue Engineering techniques utilized in an attempt to stop, restore or reverse painful degenerative changes in tissues such as joints, tendon, ligaments, nerves and intervertebral disc. These interventions are minimally invasive, cost effective, mostly performed though a needle like approach and can potentially prevent major surgical interventions and disability.Based on the specific techniques utilized, they are categorized as Biologic Stimulants (contain substances that stimulate cells to perform a specific function and Bio-Cellular Grafts (contain different type of cells, including stem cells and other tissues such as collagen, fat, bone grafts).
Biologic Stimulants Therapies (BST)
Is a type of therapy in which mostly substances are injected into the specific tissues (joints, discs, nerves, ligaments, tendons), in order to enhance the natural healing capabilities of damage or degenerative tissue. Even though, these biologic stimulants do not contain stem cells, they can be extremely effective in the treatment of early tissue damage or degeneration. We usually use several stimulants to achieve better outcomes and more frequently in combination with other bio-cellular therapies.
- Prolotherapy (Creates cellular proliferation, nutritional benefits)
- Ozone (Increases tissue oxygenation, improves healing)
- Traumeel (Homeopathic anti-inflammatory)
- Viscous Supplementation (Increases joint lubrication, sustain release of growth factors)
- Peptide Therapy (anti-inflammatory, increases protein synthesis)
- Hormone Therapy (accelerate protein synthesis, improves healing)
Bio-Cellular Graft TherapiesIs a type of Bio-Cellular Regenerative Therapy used in the treatment of moderate to advanced degenerative conditions or injuries. It utilizes your own blood derived growth factors PRP (which are chemicals that instruct cells to perform specific tasks) and stem cells derived from your bone marrow, peripheral blood or adipose tissues. These are frequently combined with your of tissue scaffolds (fibrin, adipose tissue) or synthetic (collagen, hyaluronic acid) in order to obtain the most effective results.
PRP stands for Platelet Rich Plasma.Â This is a type of therapy in which the patientâ€™s own blood is withdrawn from a vein and concentrated by a special device. Ultimately creating a concentrate of platelets in plasma. This concentrate contains up to 500% greater concentration of bioactive proteins along with multiple growth factors. They are essential in inducing and accelerating tissue repair and regeneration.Â The PRP is injected into specific tissues by using the most advanced tissue guidance with sonography (ultrasound) and fluoroscopy. Most of the benefit is seen in the connective tissues, bone, hyaline cartilages and development of new blood vessels necessary for tissue healing.
BMAC stands for Bone Marrow Aspirate Concentrate and it is obtained by aspiration of bone marrow blood, usually from your iliac crest and takes about 3 minutes. It is usually performed under local anesthesia and intravenous sedation. BMAC contains multiple types of stem cells and other important cells that produce red cells, platelets, antibodies and others. More importantly, it contains a type of stem cell called mesenchymal stem cells (MSC). These cells are responsible for secreting growth factors that can significantly enhance the tissues ability to heal and regenerate. These are the cells with the greatest capability to repair bone, cartilage and muscle. The total number of mesenchymal stem cells present in BMAC is usually .1% of the total cell population.
ADSC stands for Adipose Derived Stromal Cells. It contains a mixture of different types of stem cells and non-stem cells, which are obtained from your own adipose tissues, through a process called lipo-aspirate. The process usually takes 20 minutes and is performed under local anesthesia, frequently assisted with intravenous sedation. With a small liposuction cannula, a small amount of adipose tissue is removed, around 50cc. The lipo-aspirate is then taken to the laboratory (in houe) and the cellular components are extracted.Â The cell extract is rich in multiple type of cells, including stem cells. It contains a type of stem cell called mesenchymal stem cells (MSC). These cells are responsible for secreting growth factors that can significantly enhance the tissues ability to heal and regenerate. The number of mesenchymal stem cells (MSC) can be up to 500-800% more than in BMAC and they have greater anti-inflammatory and regenerative capabilities. The total population of MSC present in ADSC is roughly 5-8% of the cell population.
AATG stands for Allogeneic Amniotic Tissue Graft and refers to amniotic tissues and fluids obtained from donors (carefully screened with no communicable diseases) during a cesarean section. It contains collagen, growth factors and a very small percentage of live amniotic stem cells. These cells are mesenchymal in origin and are more powerful than traditional adult mesenchymal cells. We utilized amniotic grafts in patients that cannot donate their own cells or are unwilling to undergo the graft extraction procedure. The procedure consists of injecting the cryo-preserved amniotic tissue (once is thawed), under sonograhic or fluoroscopic guidance, into the affected or injured tissue. AATG has been used in the world and the US with no reported complications of communicable diseases. It does not add extra time or an additional procedure to the regenerative treatment. We occasionally combine the AATG with BMACÂ or ADSC for a more robust repair.
SCAFFOLDS are biologic grafts or materials, used in tissue engineering techniques, combined with growth factors and stem cells. It helps provide a 3D environment for the cells to be protected, proliferate and arranged them selves according to the tissue in which they are transplanted. More importantly, they act as a slow release systems for growth factors or biologic stimulants. It is an essential component in tissue engineering techniques. Scaffolds come from fibrin (obtained from your own blood), lipo-aspirate (from your own adipose tissues), collagen and Hyaluronic Acid (naturally manufactured tissue filers).â€œThese interventions are not designed as stand alone therapies and in order to achieve maximum tissue repair and regeneration may have to be repeated. It is important to continue to exercise proper ergonomics, bio-mechanics, avoidance of triggering factors, continue physical, chiropractic and massage therapy (as needed), and abide by a sound Regenerative Lifestyle. â€œ